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    公司介绍 // introduction

    上海嘉因生物科技有限公司致力于表观遗传学在科学研究和临床检测上的应用澳洲幸运5正规官网网址澳洲幸运5正规官网网址,是上海市高新技术企业澳洲幸运5正规官网网址澳洲幸运5正规官网网址,博士后创新实践基地。在科研服务领域澳洲幸运5正规官网网址,团队主要产品线有CUT&Tag/ChIP-seq澳洲幸运5正规官网网址澳洲幸运5正规官网网址澳洲幸运5正规官网网址,ATAC-seq澳洲幸运5正规官网网址,1微克MeRIP-seq, eccDNA-seq(环状DNA测序)澳洲幸运5正规官网网址,单细胞ATAC-seq和单细胞RNA-seq澳洲幸运5正规官网网址。

           嘉因生物的ChIP-seq技术协助客户发表论文十余篇澳洲幸运5正规官网网址,所发表的杂志包括Nature Communications,PNAS和Theranostics等澳洲幸运5正规官网网址;2018年8月1日嘉因生物发布了十万样本ATAC-seq测序计划澳洲幸运5正规官网网址,该计划受到北京大学李程教授澳洲幸运5正规官网网址,和同济大学江赐忠教授的高度点评澳洲幸运5正规官网网址澳洲幸运5正规官网网址澳洲幸运5正规官网网址;2019年1月,嘉因生物的ATAC-seq实验技术协助客户于The Journal of Clinical Investigation发表论文Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer澳洲幸运5正规官网网址澳洲幸运5正规官网网址,影响因子12.282分;2019年3月,嘉因生物通过了美国10X Genomics 公司的单细胞ATAC-seq产品线的CSP认证,成为国际上首家获得该产品官方认证的企业澳洲幸运5正规官网网址澳洲幸运5正规官网网址澳洲幸运5正规官网网址澳洲幸运5正规官网网址;2020年6月澳洲幸运5正规官网网址,嘉因生物协助客户在Molecular Therapy: Nucleic Acids澳洲幸运5正规官网网址,影响因子7.032澳洲幸运5正规官网网址,连发2篇MeRIP-seq文章澳洲幸运5正规官网网址澳洲幸运5正规官网网址澳洲幸运5正规官网网址。此外,2018年9月澳洲幸运5正规官网网址,嘉因生物于Plos  Biology杂志发表1微克RNA的MeRIP-seq实验文章 Refined RIP-seq protocol for epitranscriptome analysis with low input materials澳洲幸运5正规官网网址澳洲幸运5正规官网网址,开启了MeRIP-seq技术进入临床医学研究的序幕澳洲幸运5正规官网网址澳洲幸运5正规官网网址。


    嘉因生物参与发表的文章列表//article

    人和动物的文章:        

    [1] Yu S H, Zhu K Y, Chen J, et al. JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML[J]. Nature Communications, 2018. (IF: 12.353)
    [2] Ho J W K, et al. Comparative analysis of metazoan chromatin organization[J]. Nature, 2014, 512(7515): 449. (IF: 40.136)
    [3] Yamamoto S, et al. JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer[J]. Cancer Cell, 2014, 25(6): 762-777. (IF: 27.407)
    [4] Ouyang Q, et al. Distinct Role of Nuclear Receptor Corepressor 1 Regulated de novo Fatty Acids Synthesis in Liver Regeneration and Hepatocarcinogenesis[J]. Hepatology, 2017, 67(3).(IF: 13.246)
    [5] Fulciniti M, et al. Integrating Gene and Mir Expression Profiles and Regulatory Network Structures to Define Aberrent Feed Forward Loops with Functional and Clinical Implications in Myeloma [M]. Am Soc Hematology. 2012. (IF: 12.595)
    [6] Du Z, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer[J]. Nature Structural & Molecular Biology, 2013, 20(7): 908-13. (IF: 12.595)
    [7] Wang X, et al. Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma[J]. Leukemia, 2014, 28(4): 894-903. (IF:12.104)
    [8] Wang C, et al. Computational inference of mRNA stability from histone modification and transcriptome profiles[J]. Nucleic acids research, 2012, 40(14): 6414-6423. (IF: 10.162)
    [9] Dai Y J, Wang Y Y, Huang J Y, et al. Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement[J]. Proceedings of the National Academy of Sciences, 2017, 114(20): 5237-5242. (IF: 9.504)
    [10] Lin X, et al. BSeQC: quality control of bisulfite sequencing experiments[J]. Bioinformatics, 2013, 29(24): 3227-3229. (IF: 7.307)
    [11] Sun H, et al. CistromeFinder for ChIP-seq and DNase-seq data reuse[J]. Bioinformatics, 2013, 29(10): 1352. (IF: 7.307)
    [12] Zeng W, et al. Distinct Transcriptional and Alternative Splicing Signatures of Decidual CD4+ T Cells in Early Human Pregnancy[J]. Frontiers in Immunology, 2017, 8(IF:6.4)

    [13] Kong X, Wei G, Chen N, Zhao S, Shen Y, Zhang J, Li Y, Zeng X, Wu X. Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection. PLoS Pathog. 2020 Jun 8;16(6):e1008633. (IF:6.218)
    [14] Liu X Z, et al. All-transretinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells[J]. Cell Death & Disease, 2017, 8(5): e2782. (IF:5.965)

    [15] Wang J, et al. PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression[J]. Scientific Reports, 2014, 4(6186): 5008. (IF:4.259)
    [16] Ling Y, et al. ProFITS of maize: a database of protein families involved in the transduction of signalling in the maize genome[J]. Bmc Genomics, 2010, 11(1): 580. (IF: 3.729)
    [17] Li Y, et al. Classify Hyperdiploidy Status of Multiple Myeloma Patients Using Gene Expression Profiles[J]. Plos One, 2013, 8(3): e58809. (IF:2.806)
    [17] Zhang J , Wang C , Chen X , et al. EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast?cancer[J]. The EMBO Journal, 2015, 34(23):2953-2970. (IF: 10.557)
    [19] Ding Y, Li N, Dong B, et al. Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer[J]. The Journal of clinical investigation, 2019, 129(2). (IF:12.282)
    [20] Zhang W, Zhao C, Zhao J, et al. Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival[J]. Theranostics, 2018, 8(16): 4359. (IF: 8.537)

    [21] Yang J, Liu J, Zhao S, Tian F. N6-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract. Mol Ther Nucleic Acids. 2020 Jun 5;20:111-116.(IF:7.032)

    [22] Zhao W, Cui Y, Liu L, Ma X, Qi X, Wang Y, Liu Z, Ma S, Liu J, Wu J. METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification. Mol Ther Nucleic Acids. 2020 Jun 5;20:1-12. (IF:7.032)
    [23] Hua X, Xiong J W, Zhang Y J, et al. Exposure of pregnant mice to triclosan causes hyperphagic obesity of offspring via the hypermethylation of proopiomelanocortin promoter[J]. Archives of toxicology, 2019, 93(2): 547-558. (IF: 5.741)
    [24] Song SY, Meng XW, Xia Z, et al.Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane[J]. Aging,2019 ,11(19):8386-8417. (IF:5.515)
    [25] Wang Y., Zhang X., Song Q. et al. Characterization of the chromatin accessibility in an Alzheimer’s disease (AD) mouse model. Alz Res Therapy 12, 29 (2020).



    植物和真菌的文章:         

    [1] Yi X, et al. PlantGSEA: a gene set enrichment analysis toolkit for plant community[J]. Nucleic Acids Research, 2013, 41(Web Server issue): 98-103. (IF: 10.162)
    [2] Du Z, et al. agriGO: a GO analysis toolkit for the agricultural community[J]. Nucleic Acids Research, 2010, 38(Web Server issue): W64. (IF: 10.162)
    [3] Du Z, et al. Genome-wide analysis of histone modifications: H3K4me2, H3K4me3, H3K9ac, and H3K27ac in Oryza sativa L. Japonica[J]. Molecular plant, 2013, 6(5): 1463-1472. (IF:8.827)
    [4] Hale C J, et al. Identification of multiple proteins coupling transcriptional gene silencing to genome stability in Arabidopsis thaliana[J]. PLoS genetics, 2016, 12(6): e1006092. (IF:6.1)
    [5] Su Z, et al. plantsUPS: a database of plants' Ubiquitin Proteasome System[J]. Bmc Genomics, 2009, 10(1): 227. (IF: 3.729)
    [6] Yang C, et al. Integration of ATAC-Seq and RNA-Seq Identifies Key Genes in Light-Induced Primordia Formation of Sparassis latifolia [J]. International Journal of Molecular Sciences, 2020, 21, 185. (IF: 4.183)


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